Endocrine Abstracts

Introduction: tests alternative to the fasting test are necessary for the diagnosis of numerous causes of non-diabetic hypoglycaemia (NDH), that not provoked by starvation (postprandial hypoglycemia), such as insulin autoimmune syndrome (IAS) and noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS). However, there is no consensus on the most optimal test (prolonged oral glucose tolerance test (pOGTT) or mixed meal test (MMT)) in this cohort of patients.<p class="abs...

Introduction: Decreased glycemia in patients without diabetes mellitus (nondiabetic hypoglycemias; NDH) is a manifestation of severe diseases from endocrinopathies to malignant tumors. The most specific symptom of NDH is association of attack with the intake of carbohydrate-containing food. Hypoglycemia is usually manifested by neurological and mental disorders, and therefore, patients initially seek medical help not from an endocrinologist, but from psychiatrists and neurolog...

Introduction: To diagnose the hypoglycemic diseases (HD), firstly, proving the hypoglycemia presence is necessary. For this purpose, the prolonged fast test, which can reach 72 h, is performed. In case of late completion this test has a potential risk of hypoglycemic coma. Repeated glycemia control by glucometer brings discomfort to patients and increases the labor costs of medical workers. In this regard, it was relevant to conduct a study on the comparison of continuous gluc...

Introduction: Insulin autoimmune syndrome (IAS) is characterized by the development of hypoglycemia due to insulin and insulin autoantibodies (IAA) interaction. The disease has a strong association with certain alleles of HLA gene. In most cases the disease affects predisposed persons who take drugs containing the sulfhydryl groups. The IAA are also noticed in patients with other autoimmune pathology and in patients with multiple myeloma or monoclonal gammopathy. In c...

Introductionsome authors propose to conduct consistently two additional tests for differential diagnosis (DD) of NDH with the main purpose to confirm or exclude the autonomous hyperinsulinemia (AH; insulinoma): determination the capillary beta-hydroxybutyrate (BHB) during prolonged fasting test (FT), and glucagon test (GT) at the moment of hypoglycemia. GT is more labor-intensive, high-cost and lead to potential complications. Therefore, we assumed that ...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Introduction: One of the manifestations of Munchausen syndrome is the deliberate injection of insulin to achieve hypoglycemia or artificial hypoglycemia. If human insulin is injected, we will always determine high level of insulin and low level of Cpeptideatthemomentofhypoglycemia. Incasesof insulin analogues injection the diagnos is maybe difficult when we use analyzers specific only to human insulin: the low level of IRI and C peptide will be determined.<p class="abstext...

Introduction: One of the autoimmunenon-diabetic hypoglycemia (NDH) causes isthe antibodies to insulinreceptor (AB-rIRI) formation and/orinsulin resistance type B (TBIR).Objectives: To determine the prevalence of increased AB-rIRI level in patients with suspected NDH of different genesis and in healthy individuals; to determine significance of AB-rIRI investigation in NDH diagnosis.Methods: In a prospective study we determined AB-rI...

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

Introduction: Topical diagnosis of insulinoma is an actual problem due to the low detection rate of tumors (about 75%) and conflicting data about its localization in pancreas (more than 50%) when using different imaging techniques. This is partly due to the subjectivity of visualizing diagnosis specialists when describing the location of tumor. We assumed that multimodal imaging Fusion will improve the accuracy of topical diagnosis of insulinoma.Aim: To ...